Roles of phosphatidate phosphatase enzymes in lipid metabolism
نویسندگان
چکیده
منابع مشابه
Roles of phosphatidate phosphatase enzymes in lipid metabolism.
Phosphatidate phosphatase (PAP) enzymes catalyze the dephosphorylation of phosphatidate, yielding diacylglycerol and inorganic phosphate. In eukaryotic cells, PAP activity has a central role in the synthesis of phospholipids and triacylglycerol through its product diacylglycerol, and it also generates and/or degrades lipid-signaling molecules that are related to phosphatidate. There are two typ...
متن کاملPhosphatidate phosphatase, a key regulator of lipid homeostasis.
Yeast Pah1p phosphatidate phosphatase (PAP) catalyzes the penultimate step in the synthesis of triacylglycerol. PAP plays a crucial role in lipid homeostasis by controlling the relative proportions of its substrate phosphatidate and its product diacylglycerol. The cellular amounts of these lipid intermediates influence the synthesis of triacylglycerol and the pathways by which membrane phosphol...
متن کاملThe Enzymes of Lipid Metabolism
During the eight years which separate the two editions of Raffel's Immunity, the field of immunology has grown exponentially. Although the original format has been retained, many of the newer concepts, (and controversies) have been included in the current work. The first two sections of this book deal with fundamental immune responses to antigens and infectious agents. Included are chapters dea...
متن کاملPho85p-Pho80p phosphorylation of yeast Pah1p phosphatidate phosphatase regulates its activity, location, abundance, and function in lipid metabolism.
The yeast Pah1p phosphatidate phosphatase, which catalyzes the penultimate step in the synthesis of triacylglycerol and plays a role in the transcriptional regulation of phospholipid synthesis genes, is a cytosolic enzyme that associates with the nuclear/endoplasmic reticulum membrane to catalyze the dephosphorylation of phosphatidate to yield diacylglycerol. Pah1p is phosphorylated on seven (S...
متن کاملPhosphatidate metabolism in stimulated synaptosomes.
Acetylcholine increases the incorporation of 32P1 into phosphatidate of guinea-pig brain synaptosomes incubated in vitro (Durell & Sodd, 1966; Schacht & Agranoff, 1972; Yagihara & Hawthorne, 1972). Three pathways for the synthesis of phosphatidate operate in brain tissue: acylation of glycerol 3-phosphate, acylation of dihydroxyacetone phosphate (Pollock et al., 1975) and the phosphorylation of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2006
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2006.10.003